CSSedit, by MacRabbit, is a life changing CSS editor that saves us hours every week. It is honestly one of the two major reasons that I switched to the macintosh platform in 2007. Live Previews and quick searching huge CSS files are just some of the beautiful features of this programme. 

Daylite, from Marketcircle, is a great application for Calendaring and managing all the information that you need to keep about People, companies, projects, work opportunities and much more. Like CSSedit, it is the other key 3rd party application that convinced us to shift OS platforms from windows to OS X.